Systems BiologybioRxivPreprint
Perturb-seq identifies TCF7 as a central nexus linking MAPK- and Wnt-driven gene expression
Ghanem El Kassem, Anja Sieber, Bertram Klinger…·Michael Boettcher
The paper uses Perturb-seq to identify TCF7 as a key integrator of MAPK and Wnt signaling pathways through a feedback loop with EGR1.
DOI 10.64898/2025.12.15.694273