Author

Mirjam van Bentum

Max Delbrück Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Anja SieberiD· 3 shared Bertram KlingeriD· 3 shared Nils BlüthgeniD· 3 shared David SteinbrechtiD· 2 shared Florian UhlitziD· 2 shared Ghanem El KassemiD· 2 shared Jasmine Hillmer· 2 shared Jennifer von Schlichting· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersSystems Biology

Anja SieberORCID

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3 papers

Recent·Most cited

Perturb-seq identifies TCF7 as a central nexus linking MAPK- and Wnt-driven gene expression

Ghanem El Kassem, Anja Sieber, Bertram Klinger, Florian Uhlitz, David Steinbrecht, Mirjam van Bentum, Jasmine Hillmer, Jennifer von Schlichting, Reinhold Schäfer, Nils Blüthgen, Michael Boettcher

The paper uses Perturb-seq to identify TCF7 as a key integrator of MAPK and Wnt signaling pathways through a feedback loop with EGR1.

bioRxiv · Dec 16, 2025 · PreprintSystems Biology

Spike-in enhanced phosphoproteomics uncovers synergistic signaling responses to MEK inhibition in colon cancer cells

Mirjam van Bentum, Bertram Klinger, Anja Sieber, Sheyda Naghiloo, Henrik Zauber, Nadine Lehmann, Mohamed Haji, Sylvia Niquet, Philipp Mertins, Nils Blüthgen, Matthias Selbach

The paper introduces SPIED-DIA, a phosphoproteomics method, to identify synergistic signaling responses in colon cancer cells to MEK inhibition and growth factor stimulation.

Nature Communications · May 26, 2025Peer-reviewedSystems Biology

Targeted Perturb-seq Reveals EGR1 and FOS as Key Regulators of the Transcriptional RAF-MAPK Response

Ghanem El Kassem, Anja Sieber, Bertram Klinger, Florian Uhlitz, David Steinbrecht, Mirjam van Bentum, Jasmine Hillmer, Jennifer von Schlichting, Reinhold Schäfer, Nils Blüthgen, Michael Boettcher

This study uses targeted Perturb-seq to identify EGR1 and FOS as key regulators of the transcriptional RAF-MAPK response by constructing a directional interaction network.

bioRxiv · Jan 13, 2024 · PreprintSystems Biology