Author

Ghanem El Kassem

Martin Luther University Halle-WittenbergORCID 0009-0009-2623-0684Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Anja SieberiD· 2 shared Bertram KlingeriD· 2 shared David SteinbrechtiD· 2 shared Florian UhlitziD· 2 shared Jasmine Hillmer· 2 shared Jennifer von Schlichting· 2 shared Michael BoettcheriD· 2 shared Mirjam van Bentum· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersSystems Biology

Anja SieberORCID

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2 papers

Recent·Most cited

Systems BiologybioRxivPreprintDec 16, 2025

Perturb-seq identifies TCF7 as a central nexus linking MAPK- and Wnt-driven gene expression

Ghanem El Kassem, Anja Sieber, Bertram Klinger…·Michael Boettcher

The paper uses Perturb-seq to identify TCF7 as a key integrator of MAPK and Wnt signaling pathways through a feedback loop with EGR1.

DOI 10.64898/2025.12.15.694273

experimental assaygene regulatory network inference

𝕏 PostBluesky

Systems BiologybioRxivPreprintJan 13, 2024

Targeted Perturb-seq Reveals EGR1 and FOS as Key Regulators of the Transcriptional RAF-MAPK Response

Ghanem El Kassem, Anja Sieber, Bertram Klinger…·Michael Boettcher

This study uses targeted Perturb-seq to identify EGR1 and FOS as key regulators of the transcriptional RAF-MAPK response by constructing a directional interaction network.

1 citation

CRISPR screenexperimental assay

𝕏 PostBluesky