Single-Cell Proteomics Reveals Heterogeneous and Bimodal Proteome Responses to DNA Damage
Kish R. Adoni, Georgina H. Charlton, Jonathan E. Ditcham, Declan T. Cook, Jenny Ho, Joanna M Kirkpatrick, Riccardo Zenezini Chiozzi, Konstantinos Thalassinos
This study uses single-cell proteomics to show that DNA damage causes heterogeneous and bimodal proteome responses in U2 OS cells, revealing cell-to-cell variability obscured by bulk analysis.
bioRxiv · Oct 8, 2026 · PreprintCell Biology