Joanna M Kirkpatrick

This study uses single-cell proteomics to show that DNA damage causes heterogeneous and bimodal proteome responses in U2 OS cells, revealing cell-to-cell variability obscured by bulk analysis.

This study investigates sex-dependent proteomic changes in young and aged mouse peripheral nerves during ex vivo degeneration, revealing sex-specific molecular features of nerve ageing.

This study compares molecular changes in PNS ageing, dietary restriction, and injury, finding similar proteomic signatures between ageing and injury.

EstroGene2.0 is a multi-omic database that compiles data on estrogen receptor responses and resistance in breast cancer, revealing diverse transcriptomic changes and identifying key targets.

This study investigates changes in the myelin proteome of mouse peripheral nerves during aging, finding only subtle changes and proposing the dataset as a resource for future research.

The paper presents genome assemblies and gene predictions for Sf21 and Tni cell lines using multi-omics data, enabling improved use in protein expression and genome engineering.

The paper evaluates DIA performance across multiple laboratories using standardized samples and provides benchmark datasets for education and tool development.

This study shows that reduced proteasome activity in aging brains leads to ribosome stoichiometry loss and aggregation, increasing mortality risk in killifish.

The paper compares liver proteomes of long-lived naked mole-rats and short-lived guinea pigs to identify molecular networks linked to longevity and human aging.