Riccardo Zenezini Chiozzi

This study uses single-cell proteomics to show that DNA damage causes heterogeneous and bimodal proteome responses in U2 OS cells, revealing cell-to-cell variability obscured by bulk analysis.

The paper identifies an alternatively-spliced form of CHC17 (CHC17-SAS) that compensates for the absence of CHC22 in some vertebrates, enabling GLUT4 trafficking.

This study shows that chaperones shape the structural evolution of yeast prion amyloids during maturation, with Hsp104 inhibiting structural diversity.

This paper introduces a novel recombinant chymotrypsin (rChymoSelect) with enhanced cleavage specificity, improving proteome coverage and reducing missed cleavages in proteomics workflows.

The paper identifies how the HMD domain of Prf1 in the PAF1C complex activates HULC for H2B ubiquitination by repositioning its RING domains.

This paper shows metformin protects neurons by stabilizing rngo/DDI2, enhancing proteostasis and reducing toxicity in multiple neurodegenerative models.

The paper shows TBK1 phosphorylates Rab7 to regulate unidirectional retrograde transport of signalling endosomes in motor neurons, linking TBK1 dysfunction to ALS-related transport impairments.

The paper identifies a previously overlooked complex between AIFM1 and cytochrome c oxidase using mass spectrometry and proteomic approaches, revealing structural insights and potential roles in OXPHOS and cell death.