Translation Initiation Represents an Acute Myeloid Leukemia Cell Vulnerability That Can Be Co-Targeted With BCL-2 Inhibition
Yoke Seng Lee, Jonathan Good, Noha Awais, Benjamin K. Eschle, Maia S. Lineberry, Jessica L. Teo, Sarah Bibeau, Morgan Wollman, George I Karadimov, Nurefsan E. Sariipek, Jean Acosta, Jenny Noel, David G. J. Cucchi, Erica A. K. DePasquale, Prafulla C. Gokhale, , Peter van Galen
The paper identifies EIF4A1 as a vulnerability in AML cells and shows that combining Zotatifin with Venetoclax enhances apoptosis and survival in AML models.
bioRxiv · Dec 20, 2024 · PreprintCancer Biology