Jessica L. Teo

PROPEL applies programmable shear stress to endothelial cells, revealing subtype-specific mechanoadaptation thresholds and transcriptional responses across vascular beds.

This study identifies a novel S1PR1-Dll4-MPDZ-Notch1 signaling pathway that enhances endothelial barrier integrity through Notch activation and Rac1 activity.

This paper develops a 3D computational model of microvascular beds and interstitial spaces to better understand fluid flow dynamics and the effects of vascular permeability.

The paper identifies EIF4A1 as a vulnerability in AML cells and shows that combining Zotatifin with Venetoclax enhances apoptosis and survival in AML models.