Activity-dependent extracellular proteolytic cascade remodels ECM to promote structural plasticity
Jeet Bahadur Singh, Bartomeu Perelló‐Amorós, Jenny Schneeberg, Constanze I. Seidenbecher, Anna Fejtová, Alexander E. Dityatev, Renato Frischknecht
The paper shows that neuronal activity triggers brevican cleavage via proteolytic cascades, enabling structural synaptic plasticity in the rat hippocampus.
bioRxiv · Oct 28, 2024 · PreprintNeuroscience