Alexander E. Dityatev

Intrinsic Cellular Persistent Firing Sustains Hippocampal Spatial Representations during Working Memory

The paper shows that hippocampal place cells maintain spatial information through intrinsic persistent firing via TRPC4 channels during working memory tasks in mice.

Depletion of neurocan in the prefrontal cortex impairs temporal order recognition, cognitive flexibility and perisomatic GABAergic innervation

This study shows that reducing neurocan in the prefrontal cortex impairs cognitive flexibility and perisomatic GABAergic innervation in mice.

SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoids

This study shows that SNCA triplication in human midbrain organoids causes early proteostasis disruption and extracellular matrix changes before neurodegeneration.

Short Polysialic Acid Counteracts Age-Related Synaptic and Cognitive Deficits

The paper shows that short polysialic acid (NANA12) improves cognitive and synaptic function in very old mice without altering neuronal structure or inflammation markers.

Activity-dependent extracellular proteolytic cascade remodels ECM to promote structural plasticity

The paper shows that neuronal activity triggers brevican cleavage via proteolytic cascades, enabling structural synaptic plasticity in the rat hippocampus.

Neurocan regulates axon initial segment organization and neuronal activity in cultured cortical neurons

This study investigates the role of Neurocan in regulating axon initial segment organization and neuronal activity in cultured cortical neurons through knockdown and knockout approaches.

Spatio-temporal dynamics of microglia phenotype in human and murine cSVD: impact of acute and chronic hypertensive states

This study examines microglial phenotypic changes in human and murine cerebral small vessel disease under acute and chronic hypertension, identifying stage-specific morphological and surface marker alterations.

A shift in the mechanisms controlling hippocampal engram formation during brain maturation

This study shows that the maturation of hippocampal inhibitory interneurons by extracellular matrix is necessary for the development of precise episodic-like memories in mice.

Neural Extracellular Matrix Remodeling Signatures in Genetic and Acquired Mouse Models of Epilepsy

The paper investigates ECM remodeling in different epilepsy models and identifies ECM components that predict seizure properties.

Heparan sulfates regulate axonal excitability and context generalization through Ca2+/calmodulin-dependent protein kinase II

This study shows that heparan sulfates regulate axonal excitability and context generalization via CaMKII, with heparinase treatment affecting neuronal function and memory.

Extracellular Matrix Regulates Neuronal Chloride Concentration via K+-Cl--Cotransporter 2

This study shows that extracellular matrix degradation reduces KCC2 protein levels, increases intracellular chloride concentration, and alters GABAergic transmission in rat neurons.

Vascular and neural transcriptomics reveal stage-dependent pathways to inflammation and cognitive dysfunction in a rat model of hypertension

This study investigates stage-dependent molecular and cellular changes in a rat model of hypertension, revealing vascular and neural pathways linked to inflammation and cognitive dysfunction.

Extracellular matrix remodeling through endocytosis and resurfacing of Tenascin-R

The paper identifies a novel ECM remodeling mechanism through endocytosis and resurfacing of Tenascin-R near synapses, occurring within 3 days and dependent on activity.

LGI1 downregulation increases neuronal circuit excitability

This study shows that reducing LGI1 levels increases neuronal excitability and synaptic plasticity, potentially contributing to epilepsy and limbic encephalitis.

A synthetic synaptic organizer protein restores glutamatergic neuronal circuits

The paper designs and characterizes CPTX, a synthetic protein that restores synaptic function and behavior in mouse models of neurological diseases.

Epigenetic mechanism of carbohydrate sulfotransferase 3 (CHST3) downregulation in the aging brain

This study identifies age-related downregulation of CHST3 gene expression in the aging mouse brain, linked to epigenetic changes and cognitive decline.

Dopamine modulates the integrity of the perisynaptic extracellular matrix at excitatory synapses

This study shows dopamine modulates ECM integrity at excitatory synapses via D1 receptors and proteases ADAMTS-4/5, affecting brevican and aggrecan cleavage.