Constanze I. Seidenbecher

This study examines how mesoscale connectivity patterns in the medial temporal lobe relate to tau pathology and memory in older adults, finding distinct associations with age and AD pathology.

This study shows that reducing neurocan in the prefrontal cortex impairs cognitive flexibility and perisomatic GABAergic innervation in mice.

This study examines how theta power and coherence change during set-shifting in young and older adults, finding age-related differences in neural resource distribution.

This study examines age-related changes in midfrontal theta oscillations during cognitive flexibility tasks, finding reduced theta power and task modulation in older adults.

The paper shows that neuronal activity triggers brevican cleavage via proteolytic cascades, enabling structural synaptic plasticity in the rat hippocampus.

This study investigates the role of Neurocan in regulating axon initial segment organization and neuronal activity in cultured cortical neurons through knockdown and knockout approaches.

The paper examines the association between plasma TGF-β1 levels and hippocampal structure in older adults, finding a positive correlation with memory performance.

The paper investigates ECM remodeling in different epilepsy models and identifies ECM components that predict seizure properties.

The paper develops single-value fMRI scores to capture age-related differences in memory-related brain activity and links them to cognitive function in older adults.

The paper replicates a finding that DRD2/ANKK1 TaqIA A1 allele carriers show reduced learning performance in reward inhibition tasks and suggests COMT Val108/158Met Met homozygotes have lower learning bias.

The paper introduces and validates a comprehensive fMRI score, FADE-SAME, to quantify memory-related neural activity changes associated with neurocognitive aging.

This study investigates learning across the human lifespan using a go/no-go task, showing age-related differences in reward and punishment sensitivity.

This study shows dopamine modulates ECM integrity at excitatory synapses via D1 receptors and proteases ADAMTS-4/5, affecting brevican and aggrecan cleavage.