Germinal centers can persist for up to one year with declining somatic hypermutation and ongoing plasma cell output
Henry J. Sutton, Ester Marina-Zárate, Tasha K. Altheide, Arpan Pradhan, Amit A. Upadhyay, Iszac Burton, Michael Bick, Agnes A. Walsh, Mariane B. Melo, Jenny Tran, Nicole Phelps, Danny Lu, Diana Goodwin, Wen-Hsin Lee, Kipchoge N. Randall, , Shane Crotty
This study tracks germinal center responses in rhesus macaques over a year, showing prolonged GCs with declining SHM and ongoing plasma cell production.
bioRxiv · Oct 16, 2026 · PreprintImmunology