PI(3)P Signaling by VPS34 Complex II Orchestrates Macropinocytosis
Astha Neupane, Jared W. Wollman, Bijaya Pradhan, Jeremiah Donahoe, Joshua J Balster, Susmita Poudel, Brandon L. Scott, Adam D. Hoppe, Joel A. Swanson, Natalie W. Thiex
This study identifies VPS34 complex II as a regulator of macropinocytosis through PI(3)P signaling, showing its distinct role from class I PI3K activity.
bioRxiv · Sep 7, 2026 · PreprintCell Biology