Natalie W. Thiex

The paper uses CRISPR/Cas9 screens to identify PAK2 as a suppressor of macrophage proliferation in murine bone marrow-derived macrophages.

This study identifies VPS34 complex II as a regulator of macropinocytosis through PI(3)P signaling, showing its distinct role from class I PI3K activity.

This study shows that altered sterol content in macrophages affects membrane dynamics and immune signaling, leading to impaired macropinocytosis and dysregulated vesicular sorting.

This study identifies MRC1 as a key receptor for dextran uptake in macrophages via receptor-mediated endocytosis, distinguishing it from fluid-phase uptake mechanisms.

This study shows that murine macrophages under CSF1 stimulation rely on pinocytosis for solute influx and growth, with leucine affecting both protein synthesis and solute accumulation.