Cerebrospinal fluid transcriptional analyses reveals upregulation of IL-17, Type 1 interferon transcriptional pathways and neutrophil persistence genes associated with increased mortality from pneumococcal meningitis in adults
Emma C Wall, José Afonso Guerra-Assunção, Gabriele Pollara, Cristina Venturini, Veronica S Mlozowa, Theresa J Allain, David G Lalloo, Mahdad Noursadeghi, Jeremy S Brown, Robert S Heyderman
The paper identifies CSF gene expression patterns associated with increased mortality in pneumococcal meningitis, highlighting IL-17, Type 1 interferon, and neutrophil persistence pathways.
bioRxiv · Dec 7, 2018 · PreprintImmunology