Author

David Griffith Lalloo

Liverpool School of Tropical MedicineORCID 0000-0001-7680-2200Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:gene regulatory network inference· 2 Approach:benchmark study· 1 Approach:diffusion model· 1

Frequent Co-Authors

Emma CB WalliD· 3 shared José Afonso Guerra‐AssunçãoiD· 3 shared Robert S. HeydermaniD· 3 shared Cristina VenturiniiD· 2 shared Gabriele PollaraiD· 2 shared Jeremy BrowniD· 2 shared Mahdad NoursadeghiiD· 2 shared Veronica S Mlozowa· 2 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersImmunology

Emma CB WallORCID

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3 papers

Recent·Most cited

ImmunologyImmunology LettersPeer-reviewedJul 7, 2025

The CSF transcriptome in pneumococcal meningitis reveals compartmentalised host inflammatory responses associated with mortality.

José Afonso Guerra‐Assunção, Probir Chakravarty, Gabriele Pollara…·Emma CB Wall

The study compares CSF and blood transcriptomes in pneumococcal meningitis patients to identify mortality-associated inflammatory responses.

3 citations

humanbulk RNA-seq

𝕏 PostBluesky

MicrobiologybioRxivPreprintApr 30, 2024

The Streptococcus pneumoniae transcriptome in patient cerebrospinal fluid identifies novel virulence factors required for meningitis

Emma CB Wall, José Afonso Guerra‐Assunção, Marie Yang…·Jeremy Brown

The paper uses RNA sequencing of cerebrospinal fluid from meningitis patients to identify S. pneumoniae virulence factors, finding two genes linked to increased mortality and reduced infection persistence.

4 citations

𝕏 PostBluesky

ImmunologybioRxivPreprintDec 7, 2018

Cerebrospinal fluid transcriptional analyses reveals upregulation of IL-17, Type 1 interferon transcriptional pathways and neutrophil persistence genes associated with increased mortality from pneumococcal meningitis in adults

Emma C Wall, José Afonso Guerra-Assunção, Gabriele Pollara…·Robert S Heyderman

The paper identifies CSF gene expression patterns associated with increased mortality in pneumococcal meningitis, highlighting IL-17, Type 1 interferon, and neutrophil persistence pathways.

DOI 10.1101/490045

humanbulk RNA-seq

𝕏 PostBluesky