Emma CB Wall

The study compares CSF and blood transcriptomes in pneumococcal meningitis patients to identify mortality-associated inflammatory responses.

The paper uses RNA sequencing of cerebrospinal fluid from meningitis patients to identify S. pneumoniae virulence factors, finding two genes linked to increased mortality and reduced infection persistence.

The paper evaluates neutralising antibody titres against SARS-CoV-2 variant JN.1 using live-virus microneutralisation assays in vaccinated individuals, finding higher titres in monovalent vaccine recipients.

This study compares inflammatory responses and clinical outcomes between pneumococcal and meningococcal meningitis in HIV-high prevalence settings, finding worse outcomes in pneumococcal cases.

The paper identifies CSF gene expression patterns associated with increased mortality in pneumococcal meningitis, highlighting IL-17, Type 1 interferon, and neutrophil persistence pathways.