Mahdad Noursadeghi

Temporal Dynamics of Antigen-Specific T Cell Expansion in Primary SARS-CoV-2 Infection

The paper quantifies T cell response dynamics during primary SARS-CoV-2 infection, showing clone-intrinsic properties drive clonal kinetics and providing insights for vaccine design.

The CSF transcriptome in pneumococcal meningitis reveals compartmentalised host inflammatory responses associated with mortality.

The study compares CSF and blood transcriptomes in pneumococcal meningitis patients to identify mortality-associated inflammatory responses.

Evolution of T cell responses in the tuberculin skin test reveals generalisable Mtb-reactive T cell metaclones.

The paper tracks T cell responses over time in the tuberculin skin test to identify Mtb-reactive T cell metaclones that are immunodominant across individuals.

Genome-wide association analysis reveals insights into the molecular aetiology underlying dilated cardiomyopathy

This study identifies 80 genetic loci and 61 effector genes associated with dilated cardiomyopathy through GWAS and integrates transcriptomic data to uncover biological pathways and cellular states involved in the disease.

Single-cell transcriptome and T cell receptor profiling of the tuberculin skin test

The paper profiles single-cell transcriptomes and T cell receptors in human tuberculin skin tests to characterize the immune response to Mycobacterium tuberculosis.

Immune profiling of cord blood after prolonged rupture of membranes.

This study identifies transcriptomic changes in cord blood following prolonged rupture of membranes, suggesting immune responses to potential in utero infections.