GBA1 deficiency differentially affects endolysosomal trafficking in neurons versus astrocytes
Anna J. Park, Sarah Fish, Colby L. Samstag, M. Kim, Jeremy Weiss, Selina Yu, Malia L Callier, Ella H Chiu, Joshua Weiss, Christiane S. Hampe, Raja Estes, Bernice C. Lin, Arnav Khera, Dora Yearout, Leo J. Pallanck, , Marie Y. Davis
This study models GBA1 deficiency in neurons and astrocytes using iPSCs, revealing cell-type specific endolysosomal trafficking defects and -synucleinopathy in neurons, while astrocytes show neurotoxic reactivity.
bioRxiv · Jan 13, 2026 · PreprintNeuroscience