Author

Leo J. Pallanck

University of WashingtonORCID 0000-0002-5943-9339Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:Drosophila· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Evelyn S. VincowiD· 2 shared Gautam PareekiD· 2 shared Gillian MilsteiniD· 2 shared Ruth E. ThomasiD· 2 shared Anna J. ParkiD· 1 shared Arnav KheraiD· 1 shared Bernice C. LiniD· 1 shared Christiane S. HampeiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersGenetics

Evelyn S. VincowORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

GBA1 deficiency differentially affects endolysosomal trafficking in neurons versus astrocytes

Anna J. Park, Sarah Fish, Colby L. Samstag, M. Kim, Jeremy Weiss, Selina Yu, Malia L Callier, Ella H Chiu, Joshua Weiss, Christiane S. Hampe, Raja Estes, Bernice C. Lin, Arnav Khera, Dora Yearout, Leo J. Pallanck, , Marie Y. Davis

This study models GBA1 deficiency in neurons and astrocytes using iPSCs, revealing cell-type specific endolysosomal trafficking defects and -synucleinopathy in neurons, while astrocytes show neurotoxic reactivity.

bioRxiv · Jan 13, 2026 · PreprintNeuroscience

Glucocerebrosidase deficiency leads to neuropathology via cellular immune activation

Evelyn S. Vincow, Ruth E. Thomas, Gillian Milstein, Gautam Pareek, Theo K. Bammler, James W. MacDonald, Leo J. Pallanck

This study identifies macrophage activation as a key mechanism by which GBA mutations contribute to neuropathology in a Drosophila model.

PLoS Genetics · Nov 11, 2024Peer-reviewedGenetics

A Drosophila model for mechanistic investigation of tau protein spread

Kondalarao Bankapalli, Ruth E. Thomas, Evelyn S. Vincow, Gillian Milstein, Laura V. Fisher, Leo J. Pallanck

This study develops a Drosophila model to investigate tau protein spread mechanisms, finding that dynamin and GSK-3β modulate tau trafficking through endocytosis and phosphorylation.

Disease Models & Mechanisms · Sep 1, 2024Peer-reviewedNeuroscience

Inactivation of the mitochondrial protease Afg3l2 results in severely diminished respiratory chain activity and widespread defects in mitochondrial gene expression

Gautam Pareek, Leo J. Pallanck

This study investigates the role of Afg3l2 in mitochondrial function by inactivating it in Drosophila, revealing defects in mitochondrial gene expression and respiratory chain activity with potential therapeutic implications.

PLoS Genetics · Oct 19, 2020Peer-reviewedNeuroscience