Dora Yearout

GBA1 deficiency differentially affects endolysosomal trafficking in neurons versus astrocytes

This study models GBA1 deficiency in neurons and astrocytes using iPSCs, revealing cell-type specific endolysosomal trafficking defects and -synucleinopathy in neurons, while astrocytes show neurotoxic reactivity.

X-Chromosome Association Study in Latin American Cohorts Identifies New Loci in Parkinson Disease

The paper conducts an X-chromosome association study in Latin American cohorts, identifying new loci linked to Parkinson Disease and replicating previous findings.

Polygenic risk prediction and SNCA haplotype analysis in a Latino Parkinson's disease cohort

The paper constructs and validates a polygenic risk score for Parkinson's disease in a Latino cohort, finding ancestry-related biases and haplotype associations at the SNCA locus.

Homozygous CADPS2 mutations cause neurodegenerative disease with Lewy bodies in parrots

This study identifies a homozygous CADPS2 mutation in parrots causing neurodegenerative disease with Lewy bodies and reduced proteasome activity.

Characterizing the genetic architecture of Parkinson's disease in Latinos

This study conducts the first GWAS of Parkinson's disease in Latinos, identifies SNCA as significant, and finds genetic overlap with Europeans.

Genome-wide Analysis of Copy Number Variation in Latin American Parkinson's Disease Patients

The paper analyzes copy number variants in Latin American Parkinson's disease patients and finds enrichment of variants overlapping known Parkinson's genes, particularly PARK2, associated with early-onset disease.