Cellular heterogeneity and therapeutic response profiling of human IDH+ glioma stem cell cultures
Nyasha Chambwe, Scott R. Kennedy, Brendan F. Kohrn, Pavlo Lazarchuk, Mario Leutert, Guangrong Qin, Bahar Tercan, Monica Sanchez-Contreras, Weiliang Tang, Jerome J. Graber, Patrick J. Paddison, Judit Villén, Ilya Shmulevich, Raymond J. Monnat
This paper characterizes IDH+ glioma stem cell cultures to model GBM biology and therapeutic response, showing reproducible survival curves and methods to track cellular heterogeneity.
Scientific Reports · Dec 21, 2025Peer-reviewedCancer Biology