Scott R. Kennedy

This study shows that mtDNA mutations arising early in life drive age-related pathologies and that mitochondrial fusion modulates their selection, suggesting interventions targeting fusion could slow aging.

The paper uses single-nucleus RNA sequencing and spatial transcriptomics to compare oligodendrocyte functions in gray and white matter across aging and Alzheimer's Disease.

The paper characterizes the IOMM-Lee cell line as a model for NF2-wildtype malignant meningioma, identifying its genomic features, radiosensitivity, and drug response to multiple anti-cancer agents.

This study shows that reduced IGF-1 signaling extends lifespan in mammals but not in mitochondrial mutator mice, indicating that mitochondrial genome stability is essential for the longevity benefits of IGF-1 suppression.

This study shows that bisphenol A inhibits cancer-protective ESR1 signaling in human liver cells at environmentally relevant doses, suggesting it promotes liver cancer.

This paper characterizes IDH+ glioma stem cell cultures to model GBM biology and therapeutic response, showing reproducible survival curves and methods to track cellular heterogeneity.

The paper shows transcript errors generate amyloid and prion-like proteins in human cells, linking DNA damage to aging and disease.

The paper detects age-related tissue-specific accumulation of mtDNA mutations in mice and shows oxidative damage mutations are reduced with treatment.

This study investigates the effects of cadmium and Aflatoxin B1 on mtDNA mutagenesis in C. elegans, finding no effect on mutation frequency or spectrum despite mitophagy defects.

The paper identifies a mutational gradient in mtDNA that correlates with replication and influences mutation accumulation and genome composition.

The paper shows that loss of vacuolar acidity in yeast causes iron sulfur cluster defects and divergent iron homeostasis during aging.

This paper introduces CRISPR-DS, a targeted sequencing technique that improves hybridization capture, reduces PCR bias, and enables detection of ultra-low frequency mutations.