Author

Pavlo Lazarchuk

University of Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Julia M. SidorovaiD· 2 shared Maria N. Pavlova· 2 shared Bahar TercaniD· 1 shared Brendan F. KohrniD· 1 shared Crina CurcaiD· 1 shared Guangrong QiniD· 1 shared Ilya ShmulevichiD· 1 shared Jerome J. Graber· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMolecular Biology

Julia M. SidorovaORCID

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Author profile →

3 papers

Recent·Most cited

Cellular heterogeneity and therapeutic response profiling of human IDH+ glioma stem cell cultures

Nyasha Chambwe, Scott R. Kennedy, Brendan F. Kohrn, Pavlo Lazarchuk, Mario Leutert, Guangrong Qin, Bahar Tercan, Monica Sanchez-Contreras, Weiliang Tang, Jerome J. Graber, Patrick J. Paddison, Judit Villén, Ilya Shmulevich, Raymond J. Monnat

This paper characterizes IDH+ glioma stem cell cultures to model GBM biology and therapeutic response, showing reproducible survival curves and methods to track cellular heterogeneity.

Scientific Reports · Dec 21, 2025Peer-reviewedCancer Biology

Werner syndrome RECQ helicase participates in and directs maintenance of the protein complexes of constitutive heterochromatin in proliferating human cells

Pavlo Lazarchuk, Matthew Manh Nguyen, Crina Curca, Maria N. Pavlova, Junko Oshima, Julia M. Sidorova

This study shows WRN helicase maintains constitutive heterochromatin in human fibroblasts by interacting with HDAC2 and HP1, and its loss disrupts heterochromatin structure and LBR expression, contributing to aging and senescence.

Aging · Oct 17, 2024Peer-reviewedMolecular Biology

Innate immunity mediator STING modulates nascent DNA metabolism at stalled forks in human cells

Vy N. Nguyen, Salomé Brunon, Maria N. Pavlova, Pavlo Lazarchuk, R Sharifian, Julia M. Sidorova

This study shows that STING modulates nascent DNA degradation at stalled replication forks, linking replication stress to innate immunity.

bioRxiv · Apr 16, 2021 · PreprintMolecular Biology