Brendan F. Kohrn

The paper uses single-nucleus RNA sequencing and spatial transcriptomics to compare oligodendrocyte functions in gray and white matter across aging and Alzheimer's Disease.

Duplex sequencing of a Li-Fraumeni family links germline TP53 p.R181H to higher neutral-region mutagenesis and weaker blood TP53 selection, plus recurrent p.R248Q/W hits across proband tissues.

The paper characterizes the IOMM-Lee cell line as a model for NF2-wildtype malignant meningioma, identifying its genomic features, radiosensitivity, and drug response to multiple anti-cancer agents.

This paper characterizes IDH+ glioma stem cell cultures to model GBM biology and therapeutic response, showing reproducible survival curves and methods to track cellular heterogeneity.

The paper assesses PFAS toxicity across genetically diverse C. elegans strains, finding genetic variation influences susceptibility to specific PFAS structures.

The paper detects age-related tissue-specific accumulation of mtDNA mutations in mice and shows oxidative damage mutations are reduced with treatment.

This study investigates the effects of cadmium and Aflatoxin B1 on mtDNA mutagenesis in C. elegans, finding no effect on mutation frequency or spectrum despite mitophagy defects.

The paper identifies a mutational gradient in mtDNA that correlates with replication and influences mutation accumulation and genome composition.

The paper detects subclonal mutations in BCL6 super-enhancers of normal human B-cells using Duplex Sequencing, revealing conserved mutational hotspots linked to lymphomas.

This paper introduces CRISPR-DS, a targeted sequencing technique that improves hybridization capture, reduces PCR bias, and enables detection of ultra-low frequency mutations.