Author

Jesper Bruus‐Jensen

University of Copenhagen

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Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

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Anne Sofie G. LarseniD· 1 shared Annette E. LangkildeiD· 1 shared Bente FrølundiD· 1 shared Christine L. GeeiD· 1 shared Dilip NarayananiD· 1 shared J. S. KastrupiD· 1 shared John KuriyaniD· 1 shared Louise HamborgiD· 1 shared

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Anne Sofie G. LarsenORCID

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1 paper

Recent·Most cited

BiophysicsProtein SciencePeer-reviewedSep 14, 2024

Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking and kinase inhibition

Dilip Narayanan, Anne Sofie G. Larsen, Stine Juul Gauger…·Sara M. Ø. Solbak

This paper investigates how PIPA, a GHB analog, affects CaMKII hub domain conformation and stability, revealing a mechanism involving Trp403 flip and hub domain stacking that reduces kinase activity.

5 citations

structural biologyexperimental assay

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