Author

Annette E. Langkilde

University of CopenhagenORCID 0000-0003-2467-4205Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Anne Sofie G. LarseniD· 1 shared Bente FrølundiD· 1 shared Christine L. GeeiD· 1 shared Dilip NarayananiD· 1 shared J. S. KastrupiD· 1 shared Jesper Bruus‐Jensen· 1 shared John KuriyaniD· 1 shared Louise HamborgiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

Anne Sofie G. LarsenORCID

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1 paper

Recent·Most cited

Ligand-induced CaMKIIα hub Trp403 flip, hub domain stacking and kinase inhibition

Dilip Narayanan, Anne Sofie G. Larsen, Stine Juul Gauger, Ruth Adafia, Rikke Bartschick Hammershøi, Louise Hamborg, Jesper Bruus‐Jensen, Nane Griem‐Krey, Christine L. Gee, Bente Frølund, Margaret M. Stratton, John Kuriyan, J. S. Kastrup, Annette E. Langkilde, Petrine Wellendorph, Sara M. Ø. Solbak

This paper investigates how PIPA, a GHB analog, affects CaMKII hub domain conformation and stability, revealing a mechanism involving Trp403 flip and hub domain stacking that reduces kinase activity.

Protein Science · Sep 14, 2024Peer-reviewedBiophysics