Author
University of CopenhagenORCID 0000-0001-5476-6288Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
5 papers
Recent·Most cited
Malene Hall Jensen, Ioannis Panagiotis Avgeris, Nur Mehpare Kocatürk…·Francesco Bavo
The paper develops a NanoBRET assay to quantify intracellular GlyT1 target engagement in living cells, distinguishing intracellular from extracellular ligands and resolving structure-activity relationships.
Jonas Sigurd Mortensen, Francesco Bavo, Malene Hall Jensen…·Azadeh Shahsavar
This study presents cryo-EM structures of human GAT3 bound to inhibitor, substrate GABA, or in substrate-free state, revealing molecular mechanisms of inhibition and substrate recognition.
Stine Juul Gauger, Line B. Palmelund, Yongsong Tian…·Petrine Wellendorph
This study identifies allosteric factors in the CaMKII hub domain that determine GHB ligand selectivity for CaMKIIa over other isozymes.
Dilip Narayanan, Anne Sofie G. Larsen, Stine Juul Gauger…·Sara M. Ø. Solbak
This paper investigates how PIPA, a GHB analog, affects CaMKII hub domain conformation and stability, revealing a mechanism involving Trp403 flip and hub domain stacking that reduces kinase activity.
Nils Ole Dalby, Ulrike Leurs, Christina Birkedahl Falk‐Petersen…·Petrine Wellendorph
The paper shows that kinase activity affects both constitutive and agonist-induced gating of 4β1/3δ GABAA receptors in hippocampal granule cells, altering ligand efficacy and antagonist effects.