Determinants of base-pair substitution patterns revealed by whole-genome sequencing of DNA mismatch repair defective Escherichia coli
Patricia L. Foster, Brittany A. Niccum, Ellen M. Popodi, Jesse P. Townes, Heewook Lee, Wazim Mohammed Ismail, Haixu Tang
This study uses whole-genome sequencing of MMR-defective E. coli to identify base-pair substitution patterns and their determinants, revealing context-dependent mutational hotspots and strand bias.
Genetics · Jun 15, 2018Peer-reviewedGenetics