Patricia L. Foster

DNA Replication-transcription conflicts do not significantly contribute to spontaneous mutations due to replication errors in Escherichia coli

This study analyzes mutations in E. coli with mismatch repair defects and finds no significant orientation bias in mutation frequencies between genes oriented co-directionally or head-on to replication.

New complexities of SOS-induced untargeted mutagenesis in Escherichia coli as revealed by mutation accumulation and whole-genome sequencing

This study uses mutation accumulation and whole-genome sequencing to reveal new complexities in SOS-induced untargeted mutagenesis in Escherichia coli, showing sequence and DNA-strand bias in transversion mutations.

Determinants of base-pair substitution patterns revealed by whole-genome sequencing of DNA mismatch repair defective Escherichia coli

This study uses whole-genome sequencing of MMR-defective E. coli to identify base-pair substitution patterns and their determinants, revealing context-dependent mutational hotspots and strand bias.