Wazim Mohammed Ismail

MYC pathway reprogramming through a TIP60 coactivator switch in neuroendocrine lineage transition in prostate cancer

The paper identifies a TIP60 coactivator switch in neuroendocrine prostate cancer, revealing a therapeutic target for MYC-driven diseases.

Human stem cell models for group 3 medulloblastoma uncover JARID1B as a regulator of the chromatin landscape.

A Rare Multipotent Peg-like Epithelial Cell is a Candidate Cell-of-Origin for High-Grade Serous Ovarian Cancer

The paper identifies a rare multipotent epithelial cell in the fallopian tube as a potential cell-of-origin for high-grade serous ovarian cancer using multi-omic profiling and organoid models.

Single cell resolution of an epigenetic signature of persister tumor cell

The paper identifies an epigenetic signature associated with persister tumor cells in ovarian cancer that correlates with chemotherapy resistance and defines the persister state.

A scalable algorithm for clonal reconstruction from sparse time course genomic sequencing data

The paper introduces a scalable algorithm for clonal reconstruction from sparse time course genomic sequencing data, achieving fast and accurate results on simulated and real data.

Single cell multiomic analyses reveal divergent effects of DNMT3A and TET2 mutant clonal hematopoiesis in inflammatory response

This study uses single cell multiomic analyses to show DNMT3A mutations in clonal hematopoiesis worsen inflammatory outcomes in COVID-19 by increasing IL32 expression and chromatin accessibility.

New complexities of SOS-induced untargeted mutagenesis in Escherichia coli as revealed by mutation accumulation and whole-genome sequencing

This study uses mutation accumulation and whole-genome sequencing to reveal new complexities in SOS-induced untargeted mutagenesis in Escherichia coli, showing sequence and DNA-strand bias in transversion mutations.

Clonal reconstruction from time course genomic sequencing data

This paper develops algorithms to reconstruct clonal evolution from time course genomic sequencing data, achieving accurate results on both simulated and experimental data.

Determinants of base-pair substitution patterns revealed by whole-genome sequencing of DNA mismatch repair defective Escherichia coli

This study uses whole-genome sequencing of MMR-defective E. coli to identify base-pair substitution patterns and their determinants, revealing context-dependent mutational hotspots and strand bias.