Brittany A. Niccum

This study analyzes mutations in E. coli with mismatch repair defects and finds no significant orientation bias in mutation frequencies between genes oriented co-directionally or head-on to replication.

This study uses mutation accumulation and whole-genome sequencing to reveal new complexities in SOS-induced untargeted mutagenesis in Escherichia coli, showing sequence and DNA-strand bias in transversion mutations.

This study uses whole-genome sequencing of MMR-defective E. coli to identify base-pair substitution patterns and their determinants, revealing context-dependent mutational hotspots and strand bias.