In vivo selection and glymphatic delivery of AAV5 capsids engineered to target human glial progenitor cells
Alexander Cona, Evan J. Newbold, Deniz Kesmen, Rajiv Snape, Jessica Danner, Nicholas White, William Borden, Abigail Iseson, Steven J. Schanz, Devin Chandler-Militello, Xiaojie Li, Jose Carlos Cano, John N. Mariani, Maiken Nedergaard, Abdellatif Benraiss, Steven A. Goldman
The paper describes engineering AAV5 capsids to target human glial progenitor cells and uses glymphatic delivery to achieve efficient brain-wide transduction with minimal off-target effects.
bioRxiv · Jul 3, 2025 · PreprintNeuroscience