Maiken Nedergaard

This study maps glymphatic transport in the spinal cord using imaging and shows that it is disrupted after injury, with impaired clearance and worsened outcomes in AQP4-knockout mice.

This study shows mechanical ventilation and anesthesia impair glymphatic function in mice, leading to delirium-like behavior.

This study links noradrenergic infraslow rhythms during sleep to heart rate variability and memory consolidation across species.

This study uses SPECT/CT to compare CSF dynamics in pigs and rats under different anesthetics, finding species- and anesthesia-specific differences in tracer distribution and clearance.

This study shows that α2-adrenergic agonist anesthesia increases glymphatic CSF influx, independent of tracer injection duration, compared to isoflurane.

This paper introduces an ultra-high-resolution MRI framework to map perivascular spaces (PVS) across the whole brain, revealing their hierarchical organization along vascular trees.

This study shows that automatic deep learning models for mouse sleep scoring struggle to generalize across labs due to signal variability and label noise, and proposes four robust models trained on diverse data.

The paper investigates coordinated infraslow cortical oscillations of multiple neuromodulators during NREM sleep in mice and finds they are regulated by specific neural circuits.

The paper describes engineering AAV5 capsids to target human glial progenitor cells and uses glymphatic delivery to achieve efficient brain-wide transduction with minimal off-target effects.

The paper introduces a mouse line for labeling blood and interstitial fluid with fluorescent proteins to study vascular structure and permeability in vivo.

This paper develops an AI velocimetry method to infer 3D CSF flow in mice, including pressure, shear stress, and flow rates, with uncertainty quantification.

This study uses high-resolution MRI to map glymphatic transport in deep brain regions by directly infusing Gd into the lateral ventricle and analyzing PVS signal enhancements.

The paper investigates how vasomotor pulsation drives cerebrospinal fluid and electrophysiological dynamics during sleep in humans.

This study shows glymphatic clearance is increased during sleep and anesthesia and reduced during wakefulness, with tracer dose adjustments needed for accurate comparison across brain states.

This paper uses CRISPR/Cas9 to knock-in a fluorescent albumin gene in mice, enabling long-term visualization of cerebral circulation in both infant and adult mice.

The paper identifies and characterizes SLYM, a potential fourth meningeal membrane, using imaging and histological analysis in mice.

The paper presents image analysis techniques for in vivo quantification of cerebrospinal fluid flow using fluorescent microspheres and discusses methods for measuring arterial diameter changes and applying these techniques to cervical lymphatic vessels.

This study shows that visual evoked potentials change in early tauopathy, suggesting they could be a biomarker for early disease stages.

This study examines how AQP4 deletion affects glymphatic function using diffusion MRI techniques, finding altered brain fluid dynamics and reduced glymphatic influx in AQP4 KO mice.

The paper investigates early neuronal activity impairments in the rTg4510 tauopathy mouse model, finding reduced responsivity and altered oscillatory patterns in visual cortex neurons.

This study investigates how locus coeruleus-norepinephrine system activity and astrocytic responses change during sleep states, revealing dynamic fluctuations in norepinephrine levels and their relationship to sleep processes.

The paper models glymphatic flow as a network of hydraulic resistances under different parametric scenarios to identify key parameters influencing CSF dynamics.

The paper demonstrates that bulk CSF flow in periarterial spaces is not an artifact of injection, using a dual-syringe system that prevents volume changes and pressure increases.

This study investigates the impact of propionic acidemia on astrocytes, finding minimal alterations in both in vitro and in vivo models, suggesting astrocytes may not be a primary target for therapy.

This study quantifies how sleep affects physiological brain pulsations and shows that spectral entropy of these pulsations can distinguish sleep from awake states.

The paper reconciles fluid dynamics theory, simulation, and in vivo measurements of CSF flow in mouse brains by applying realistic boundary conditions.

This study links an AQP4 haplotype to variations in NREM slow wave energy and cognitive performance during wakefulness in humans.

This study shows human glial progenitor cells can remyelinate both congenitally and acutely demyelinated adult CNS regions, extending lifespan and restoring function in mouse models.

The paper shows that the observed shapes of perivascular spaces (PVSs) in the brain have lower hydraulic resistance than concentric, circular annuli, allowing faster cerebrospinal fluid flow.

This study confirms that AQP4 is essential for glymphatic fluid and solute transport in the rodent brain, as Aqp4 disruption reduces CSF influx and amyloid-beta efflux.