Author

Jessica Schmitt

University of British Columbia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:yeast· 2 Organism:Drosophila· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Barry P. YoungiD· 2 shared Christopher J. R. LoeweniD· 2 shared Douglas W. AllaniD· 2 shared Jesse T. ChaoiD· 2 shared Paul PavlidisiD· 2 shared Sanja RogićiD· 2 shared Benjamin BoehmeiD· 1 shared Bill WangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersNeuroscience

Barry P. YoungORCID

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2 papers

Recent·Most cited

A Cell-Based Assay to Categorize Variants of Human Succinate Semialdehyde Dehydrogenase Associated with Autism Spectrum Disorder

Barry P. Young, Isaac Robinson, Jessica Schmitt, Brian T. F. Wu, Jie Liu, Jesse T. Chao, Sanja Rogić, Paul Pavlidis, Douglas W. Allan, Christopher J. R. Loewen

The paper develops a yeast growth assay to assess the functional impact of ALDH5A1 variants linked to autism spectrum disorder, showing they range from loss of function to normal activity.

bioRxiv · Jan 16, 2026 · PreprintNeuroscience

Revealing function-altering MECP2 mutations in individuals with autism spectrum disorder using yeast and Drosophila

Eric Chen, Jessica Schmitt, Graeme McIntosh, Barry P. Young, Tianshun Lian, Jie Liu, Kexin K Chen, J Beatrice Liston, Lily MacDonald, Bill Wang, Sònia Medina Giró, Benjamin Boehme, Mriga Das, Seevasant Indran, Jesse T. Chao, , Christopher J. R. Loewen

The paper assesses nine MECP2 variants in ASD using yeast and Drosophila assays, finding four as loss of function and five as functional, highlighting non-methyl DNA-binding roles.

Genetics · Jun 23, 2025Peer-reviewedNeuroscience