Jesse T. Chao

A Cell-Based Assay to Categorize Variants of Human Succinate Semialdehyde Dehydrogenase Associated with Autism Spectrum Disorder

The paper develops a yeast growth assay to assess the functional impact of ALDH5A1 variants linked to autism spectrum disorder, showing they range from loss of function to normal activity.

Cellular mechanism linking endoplasmic reticulum inheritance and cell cycle regulation of the nuclear genome

This study identifies a molecular mechanism linking ER stress to cell cycle regulation through Bud2 and Shs1, showing how ER integrity affects mitotic fidelity.

Revealing function-altering MECP2 mutations in individuals with autism spectrum disorder using yeast and Drosophila

The paper assesses nine MECP2 variants in ASD using yeast and Drosophila assays, finding four as loss of function and five as functional, highlighting non-methyl DNA-binding roles.

Functional assessments of PTEN variants using machine-assisted phenotype scoring

The paper introduces a new software tool, MAPS, that uses deep learning to analyze cell phenotypes from high-content microscopy, enabling rapid functional assessment of genetic variants.

Sentinel Interaction Mapping (SIM) - A generic approach for the functional analysis of human disease gene variants using yeast

The paper introduces a method to assess the functional impact of human disease gene variants using yeast-based assays.