Unfold to refold: Tracking the initial steps of PrPC unfolding in the context of PrPSc propagation
Sanaz Sabzehei, Marta Rigoli, Raul Cacheiro, Iria Díaz-Arias, Hasier Eraña, Rubén P. Lago, Arcadio Guerra, Human Rezaei, Joaquı́n Castilla, Emiliano Biasini, Víctor M. Sánchez‐Pedregal, Manuel Martín‐Pastor, Jesus R. Requenaa
The paper investigates the early steps of PrPC unfolding during PrPSc propagation using NMR and simulations, identifying key regions and mechanisms of unfolding/refolding.
bioRxiv · Oct 11, 2025 · PreprintBiochemistry