Emiliano Biasini

This study investigates how deletion of the central region of PrP affects its structure and dynamics, revealing altered conformational behavior and membrane interactions linked to neurotoxicity.

The paper investigates the early steps of PrPC unfolding during PrPSc propagation using NMR and simulations, identifying key regions and mechanisms of unfolding/refolding.

The paper identifies cryptic phosphosites in the human proteome that are buried in the protein core and may influence folding and degradation, with implications for cancer.

This study examines gene expression changes in trigeminal ganglia of Shank3b and Cntnap2 mutant mice to understand tactile sensory deficits in autism.

The paper shows that ligands binding to PrPC induce its proteolytic release, which has neuroprotective effects, and identifies mechanisms and exceptions in this process.

This study shows that defective cyclophilin A (PPIA) leads to TDP-43 proteinopathy, contributing to ALS and FTD by disrupting TDP-43 function and causing neurodegeneration.

The paper studies zebrafish impg2a and impg2b proteoglycans, their expression patterns, and structural conservation to model IMPG2-related retinal diseases.