Author

Manuel Martín‐Pastor

Universidade de Santiago de CompostelaORCID 0000-0001-6024-1656Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Arcadio GuerraiD· 2 shared Hasier ErañaiD· 2 shared Human RezaeiiD· 2 shared Iria Díaz-AriasiD· 2 shared Joaquı́n CastillaiD· 2 shared Sanaz Sabzehei· 2 shared Víctor M. Sánchez‐PedregaliD· 2 shared Emiliano BiasiniiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersBiochemistry

Arcadio GuerraORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 14, 2026

Unfolding of the disease-linked bank vole prion protein E200K in the context of PrPSc propagation

Sanaz Sabzehei, Hasier Eraña, Iria Díaz-Arias…·Manuel Martín‐Pastor

This study investigates the early unfolding events of the E200K mutant prion protein in bank voles, comparing it to the wild-type protein to understand its enhanced capacity to generate PrPSc.

DOI 10.64898/2026.10.13.759008

mouseprotein structure

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BiochemistrybioRxivPreprintOct 11, 2025

Unfold to refold: Tracking the initial steps of PrPC unfolding in the context of PrPSc propagation

Sanaz Sabzehei, Marta Rigoli, Raul Cacheiro…·Jesus R. Requenaa

The paper investigates the early steps of PrPC unfolding during PrPSc propagation using NMR and simulations, identifying key regions and mechanisms of unfolding/refolding.

DOI 10.1101/2025.10.11.681810

structural biologystatistical model

𝕏 PostBluesky