Author

Jia-He Qiu

Peking University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:protein design· 2 Approach:deep learning· 1 Approach:machine learning (classical)· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Yun‐Dong WuiD· 2 shared Cuizhen WangiD· 1 shared Hui-si Huang· 1 shared Jian‐bo WangiD· 1 shared Jianan CheniD· 1 shared Ke-Wei CheniD· 1 shared Kewei CheniD· 1 shared Kin Kuan HoiiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBioinformatics

Yun‐Dong WuORCID

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2 papers

Recent·Most cited

SAKPE: A Site Attention Kinetic Parameters Prediction Method for Enzyme Engineering

Jia-He Qiu, Zongying Lin, Kewei Chen, Tian‐Yu Sun, Xian Zhang, Yuan Li, Yonghong Tian, Yun‐Dong Wu

SAKPE predicts enzyme kinetic parameters with improved accuracy by incorporating weighted protein representations, outperforming existing methods in kcat, Km, and Ki predictions.

bioRxiv · Apr 30, 2025 · PreprintBioinformatics

A De Novo Design Strategy to Convert FAcD from Dimer to Active Monomer

Ke-Wei Chen, Cuizhen Wang, Hui-si Huang, Xing Wu, Jianan Chen, Jia-He Qiu, Kin Kuan Hoi, Tianyu Sun, Jian‐bo Wang, Yun‐Dong Wu

This paper presents a de novo design strategy to convert the dimeric enzyme FAcD into an active monomer, achieving high catalytic activity with a mutant showing improved thermal stability.

bioRxiv · Jan 11, 2025 · PreprintBioengineering