Yun‐Dong Wu

SAKPE predicts enzyme kinetic parameters with improved accuracy by incorporating weighted protein representations, outperforming existing methods in kcat, Km, and Ki predictions.

This paper presents a de novo design strategy to convert the dimeric enzyme FAcD into an active monomer, achieving high catalytic activity with a mutant showing improved thermal stability.

The paper develops a method using molecular dynamics simulations to estimate residue-specific accuracy of protein structure models, achieving performance comparable to state-of-the-art methods within a short simulation time.