MERFISH-based pooled genetic screening reveals cell non-autonomous phenotypes in intact tissue
Kang Jin, Reuben A. Saunders, Jiahao Zhang, Jiaqi Lu, Aaron R. Halpern, Jaspreet Sandhu, Xingjie Pan, Cosmos Yuqi Wang, Alexander M. Li, William E. Allen, Jonathan S. Weissman, Xiaowei Zhuang
The paper introduces an imaging-based pooled screening method to identify genetic perturbations and their effects on cell states and neighboring cells in intact tissues.
bioRxiv · Oct 6, 2026 · PreprintGenomics