LARP7 is a BRCA1 ubiquitinase substrate and regulates genome stability and tumorigenesis
Fang Zhang, Pengyi Yan, Huijing Yu, Huangying Le, Zixuan Li, Jiahuan Chen, Xiaodong Liang, Shiyan Wang, Weiting Wei, Li Liu, Yan Zhang, Xing Ji, Anyong Xie, Wantao Chen, Ze‐Guang Han, , Bing Zhang
This study shows BRCA1/BARD1 ubiquitinates LARP7, leading to its degradation and affecting DNA repair, cell cycle, and tumor resistance.
Cell Reports · Aug 1, 2020Peer-reviewedMolecular Biology