Author

Huangying Le

Shanghai Jiao Tong University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genetic & Genomic Medicine· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Anji Wei· 1 shared Anyong XieiD· 1 shared Baoxue GeiD· 1 shared Bing ZhangiD· 1 shared Di YiniD· 1 shared Fang ZhangiD· 1 shared Huijing YuiD· 1 shared Jiahuan Chen· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Anji Wei

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cross-Platform Omics Pipeline for Integrated Transcriptomics

Lianchong Gao, Huangying Le, Xin Zou, Jie Hao

CrosPIT provides a cross-platform pipeline for integrated transcriptomics analysis, enabling scalable and reproducible workflows across languages and hardware.

bioRxiv · Jun 11, 2025 · PreprintBioinformatics

In Vivo CRISPR Gene Editing in Patients with Herpes Stromal Keratitis

Anji Wei, Di Yin, Zimeng Zhai, Sikai Ling, Huangying Le, Lijia Tian, Jianjiang Xu, Søren R. Paludan, Yujia Cai, Jiaxu Hong

This study evaluates the safety and efficacy of in vivo CRISPR gene editing targeting HSV-1 in patients with herpes stromal keratitis, finding no detectable off-target effects or adverse events over 18 months.

medRxiv · Feb 21, 2023 · PreprintGenetic & Genomic Medicine

LARP7 is a BRCA1 ubiquitinase substrate and regulates genome stability and tumorigenesis

Fang Zhang, Pengyi Yan, Huijing Yu, Huangying Le, Zixuan Li, Jiahuan Chen, Xiaodong Liang, Shiyan Wang, Weiting Wei, Li Liu, Yan Zhang, Xing Ji, Anyong Xie, Wantao Chen, Ze‐Guang Han, , Bing Zhang

This study shows BRCA1/BARD1 ubiquitinates LARP7, leading to its degradation and affecting DNA repair, cell cycle, and tumor resistance.

Cell Reports · Aug 1, 2020Peer-reviewedMolecular Biology