Ze‐Guang Han

Lzp Ablation Ameliorates Dyslipidemia and Suppresses Atherosclerosis by Reducing Circulating Apolipoprotein B-Containing Lipoproteins

This study shows that deleting Lzp in mice reduces plasma lipids and atherosclerosis by lowering ApoB-containing lipoproteins.

Single-cell and single-variant resolution analysis of clonal evolution in human liver cancer

The paper analyzes clonal evolution in liver cancer at single-cell and single-variant resolution, revealing genetic and phenotypic heterogeneity and their evolutionary relationships.

A Novel Neoantigen Discovery Approach based on Chromatin High Order Conformation

This paper identifies that immuno-positive neoantigens cluster in 3D genome regions and are enriched in active chromosomal compartments, suggesting 3D genome information can improve neoantigen prioritization.

LARP7 is a BRCA1 ubiquitinase substrate and regulates genome stability and tumorigenesis

This study shows BRCA1/BARD1 ubiquitinates LARP7, leading to its degradation and affecting DNA repair, cell cycle, and tumor resistance.

Investigating higher order interactions in single cell data with scHOT

The paper introduces scHOT, a method to detect changes in higher order gene interactions in single-cell data, demonstrating its application in liver development and spatial gene correlation patterns.

scMerge: Integration of multiple single-cell transcriptomics datasets leveraging stable expression and pseudo-replication

scMerge integrates multiple scRNA-Seq datasets by removing unwanted variation through stably expressed genes and pseudo-replicates, enhancing biological discovery.