Author

Jian Hui Chang

Nanjing University

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Biology Disciplines

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Biochemistry· 1

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Organism:Arabidopsis· 1 Research Focus:cell type annotation· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Chengyi Liu· 1 shared Cuiping LiuiD· 1 shared Elena V. RomanovaiD· 1 shared Fan Li· 1 shared Guo ZhangiD· 1 shared Huiying WangiD· 1 shared Jian JingiD· 1 shared Jonathan V. SweedleriD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Chengyi Liu

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1 paper

Recent·Most cited

Distal conformational steering by N-terminal pyroglutamylation enables subtype-selective GPCR activation across Aplysia PRXamide and human Neuromedin U signaling

Jian Hui Chang, Wei-Jia Liu, Shao-Qian Wu, Elena V. Romanova, Chengyi Liu, Cuiping Liu, Xing Pan, Fan Li, Xueying Ding, Ruiting Mao, Huiying Wang, Juping Xu, Ping Fu, Yi-Long Zhang, Qingchun Jin, , Jian Jing

The paper shows how N-terminal pyroglutamylation (pQ) biases GPCR activation by altering ligand conformation and receptor pocket mechanics, enabling subtype-selective signaling in both Aplysia and human systems.

bioRxiv · Jul 30, 2026 · PreprintBiochemistry