Jonathan V. Sweedler

The paper shows how N-terminal pyroglutamylation (pQ) biases GPCR activation by altering ligand conformation and receptor pocket mechanics, enabling subtype-selective signaling in both Aplysia and human systems.

This paper shows that Enterococcus faecalis reduces Pseudomonas aeruginosa's production of quinolone signals and pyocyanin through ornithine, enabling mutualistic survival in co-culture.

This study identifies D-serine and non-conventional GluN1-GluN3 NMDARs as regulators of enteric neuron activity and gut motility in mice and guinea-pigs.