Cuiping Liu

The paper shows how N-terminal pyroglutamylation (pQ) biases GPCR activation by altering ligand conformation and receptor pocket mechanics, enabling subtype-selective signaling in both Aplysia and human systems.

This paper uses humanized mice to study how HIV resistance to broadly neutralizing antibodies (bNAbs) affects the efficacy of AAV-delivered immunotherapy, finding that escape mutation fitness costs and resistance benefits determine therapeutic success.

This study shows that macaques can elicit human-like broadly neutralizing antibodies against influenza HA stem regions, with similar immunogenetic and structural features.