ClonoScreen3D-CRISPRi Uncovers Genetic Modifiers of Radiation Response in Glioblastoma
Sukjun Lee, Anke Husmann, Jianbin Li, Chao Zheng Li, Dr sunil modi, Saif S. Ahmad, Simon Paul Mackay, Andrew Paul, Mark R. Jackson, Anthony J. Chalmers, Nicola McCarthy, Natividad Gomez-Roman, Erica Bello
This study introduces ClonoScreen3D-CRISPRi, a 3D clonogenic survival assay combined with CRISPRi, to identify genetic modifiers of radioresistance in GBM, finding NFKB2, RELB, and CDK9 as potent radiosensitizers.
bioRxiv · Apr 23, 2026 · PreprintCancer Biology