Erica Bello

This study introduces ClonoScreen3D-CRISPRi, a 3D clonogenic survival assay combined with CRISPRi, to identify genetic modifiers of radioresistance in GBM, finding NFKB2, RELB, and CDK9 as potent radiosensitizers.

The paper validates an Alzheimer's disease-associated SNP in PTK2B that alters microglial function through changes in chromatin accessibility and gene expression.

The paper generates a molecular map of human in vitro myelopoiesis from iPSC to macrophages, revealing conserved regulatory networks and new myeloid progenitors.

Meta-analysing UK Biobank family-history GWAS with diagnosed-AD GWAS yields 37 loci, four novel (NCK2, TSPAN14, SPRED2, CCDC6); fine-mapping, colocalisation and network scoring prioritize causal genes.